Abstract
The effect of 3-chloroisoxazole-5-carboxylic acid (CIC) on lipid and carbohydrate metabolism has been investigated. CIC lowered plasma NEFA levels in fasted glucose-primed rats and was significantly more active than 5-methylpyrazole-3-carboxylic acid (MPC). Both CIC and MPC had hypoglycaemic activity. With both CIC and MPC the fall in plasma NEFA always preceded the fall in blood sugar levels. CIC and MPC reduced the blood sugar and plasma NEFA in alloxan diabetic rats. CIC and MPC inhibited the basal and adrenaline and growth hormone stimulated NEFA release from in vitro rat epididymal fat pads. This CIC inhibition of growth hormone stimulated NEFA release was confirmed in intact rabbits. It seems that both MPC and CIC inhibit triglyceride breakdown in adipose tissue and that the effect upon blood glucose levels is probably secondary to the effect on fat metabolism.
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