Abstract
A histological study was conducted to determine the effects of tepa, an aziridine-alkylating agent, on male spruce budworm pupae. The results indicated an increase in protein concentration in the fat body and testes of the tepa-treated insects. The profound changes in protein metabolism in the tepa-treated insects are similar to known protein patterns in fat bodies that are mediated by increases in ecdysone titer during the pupal period. These changes are further evident in the eye and testes pigment production and in the differentiating sperm that result in sterile gametes which all depend on ecdysone titer for their normal development. From this it seems evident that tepa may have an effect on the cell's ability to regulate hormone levels, protein metabolism, or both. And these effects result in the critical changes in mature sperm that lead to the dominant lethal mutation occurring in resulting zygotes.
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