Abstract
Citric Acid and Bone MetabolismAlthough the skeleton contains a high concentration of citrate (about 1 per cent in rabbit cortical bone) the origin of this citrate has been disputed. Armstrong and Singer66 support the idea that the major part of the skeletal mineral citrate occurs adventitiously owing to the constant presence in body fluids of citrate originating from nonskeletal tissues. On the other hand, since Dixon and Perkins67 described what appeared to be an enzyme mechanism for accumulating a high, local concentration of citric acid, it was suggested that the bone mineral citrate is derived from bone cells and . . .
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