Abstract
The practicable safe tracer dose of colloidal gold-198 for measuring liver blood flow in humans is found to be 0.1 mu c/kg. This result was obtained by giving 30 mu c of colloidal gold-198 to dogs intravenously. 24 hours later the dogs were sacrificed and the distribution of the colloidal gold198 was determined in selected tissues. The liver uptake is 90.65%, and the differential absorption ratio of liver is 36.2%. From these data the safer tracer dose is calculated as 0.088 to 0.125 mu c/kg. In the latter the maximum permissible exposure is O.1r/day and in the former 0.3r/ day. (N.W.R.)
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