Abstract
It has been shown that when exogenous UDP-glucose is added to a rat-liver supernatant system which converted [ 14C]orotic acid to UDP-glucose via the polyphosphate uridine nucleotides, autoinhibition of the synthesis of this coenzyme occurred. This phenomenon has been shown to be due to a mass-action effect. As a consequence, the UTP pool in the inhibited system is maintained at a high level, and accordingly, the synthesis of cytidine nucleotides, and the labeling of the s-RNA of the preparation were increased.
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