Some compounds isolated from leaves of Lumnitzera racemosa growing in Vietnam

Duc Trung Nguyen,Mai Thi Thanh Nguyen,Phung Kim Phi Nguyen,Phuong Hoai Nguyen,Thuy Thi Le Nguyen

doi:10.32508/stdjns.v1it4.494

Abstract

From L. racemosa leaves eight compounds were isolated: myricetin (1), quercetin (2), myricetin 3-O-α-L-rhamnopyranoside (3), myricetin 3-O-(2"-O-galloyl-α-L-rhamnopyranoside) (4), myricetin 3-O-(3"-Ogalloyl-α-L-rhamnopyranoside) (5), 3-Omethylellagic acid (6), (3S,5R,6S,7E)-3,5,6- trihydroxy-7-megastigmen-9-one (7) and gallic acid (8). Their chemical structures were unambiguously elucidated by analysis of 1D and 2D NMR and high resolution ESI mass spectroscopic data, as well as by comparison with those reported in the literature. The α- glucosidase inhibition was evaluated on isolated compounds. Among them, 1, 4, 5, 6 and 8 exhibited good activities with the IC50 values in the range of 1.3-19.3 µM.

Highlights

Lumnitzera racemosa, an Indo-West Pacific mangrove plant, wildly grows in many mangrove forests in Vietnam
Some reports on the chemical constituents of Lumnitzera racemosa have been reported and there had one study on the antioxidant and cytotoxic activities of this plant growing in Vietnam [3]
Isolation and purification of compounds from Lumnitzera racemosa leaves were performed using combinations of chromatographic fractionation of some ethyl acetate extracts to afford eight compounds (1–8) (Fig. 3). Their δH 7.24 (2H, s) was characteristic of a symmetric B ring. These spectral data revealed the presence of a myricetin skeleton

Summary

INTRODUCTION

Lumnitzera racemosa, an Indo-West Pacific mangrove plant, wildly grows in many mangrove forests in Vietnam. Some extracts from Lumnitzera racemosa leaves were reported to possess bioactivities, e.g. antimicrobial, hepatoprotective and antioxidant. This species was traditionally used to treat asthma, diabetes and snake bite. Some reports on the chemical constituents of Lumnitzera racemosa have been reported and there had one study on the antioxidant and cytotoxic activities of this plant growing in Vietnam [3]

MATERIALS AND METHOD General

RESULTS AND DISCUSSION

C D Acarb 1