Abstract
AbstractThe efflux of 45Ca2+ and 3H‐GABA from cat cerebral cortex has been measured in vivo by a superfusion technique. Under control conditions, the efflux of both these isotopes is sensitive to increments in the calcium concentration of the superfusion medium but insensitive to the addition of 25 mM GABA. After 40 min of contact with medium containing 25 mM glutamate, however, neither 45Ca2+ nor 3H‐GABA efflux is affected by added Ca2+ but 3H‐GABA efflux becomes considerably enhanced by 25 mM GABA. The mean membrane potentials at this time were found to be less than controls. Depolarization generally continued past this time, recovery beginning 150 min after superfusion with glutamate. Peaks in 45Ca2+ efflux were also correlated with seizure activity which was sometimes elicited by topical glutamate. It is suggested that the transport systems for Ca2+ and GABA may be sensitive to states of neural activity, such as spreading depression.
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