Abstract
Abstract Isolated strips of human bronchi obtained during thoracic surgery exhibited pharmacological responses very similar to those of other species (e.g. guinea-pig). Analysis of the action of some sympathomimetic amines indicated that the human bronchi also possess a sparse population of α-adrenoceptors. Propranolol (>1 μg/ml) had a direct bronchoconstricting action, whereas another β-adrenoceptor blocking agent, alprenolol, produced bronchodilatation. Phentolamine (>4 μg/ml) also produced a bronchodilatation of its own. Theophylline and dibutyryl cyclic AMP produced dose-dependent relaxations. The strips were effectively contracted by acetylcholine, histamine, prostaglandin F2α (PGF2α), slow reacting substance (SRS) and bradykinin. Bradykinin, regardless of the dose, produced bronchoconstriction in some preparations and dilatation in others. 5-Hydroxytryptamine produced bronchodilatation but at very high concentrations a constriction was obtained.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
