Some biological properties of aminosteroids.

Abstract

THIS report concerns some biological properties of a steroid, 17-amino- 4-androsten-3-one monohydrochloride, designated by the code number, Su-1621.2 A few preliminary observations are included on a related steroid, Su-1092, 20-amino-3β-hydroxy-5-pregnene monohydrochloride. Su-1621, unlike testosterone of which it is an amino derivative, was found to have essentially no effects on the reproductive tract. Further studies showed that it had, nevertheless, definite biological actions in female but not male rats. Among these effects were a remarkable increase in kidney weight and lesser increases in liver and adrenal weight together with a decrease in thymus weight, growth rate and appetite. Subsequently, when it is said that animals were responsive to the compound the responsiveness was judged by this quintet of effects of which the change in kidney weight was always the most striking and reliable. Dr. C. Riley Houck of the University of Tennessee has studied the effects of Su-1621 in dogs with particular re...