Abstract
Following the introduction of atomic absorption spectrometric (AAS) instrumentation about 30 years ago, many specific and sensitive methods for determining trace metal concentrations in biological materials were developed. Yesterday's rare and esoteric investigations are today's routine clinical analyses. Levels of essential and toxic metals can be determined with relative ease for diagnostic purposes and following response to treatment. There is greater understanding of the chemistry and biochemistry of trace metals in health and disease as a consequence.
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