Abstract

The reaction of 4-[1,2,3,4-tetrahydroquinazolin-2,4-dion-3-yl]benze-nesulfonamide 4 and 4-[2-thioxo-1,2,3,4 tetrahydroquniazolin-4-on-3-yl]benznesulfonamide 5 with chloromethylethyl ether, chloromethylbenzyl ether, and (2-acetoxyethoxy)methyl bromide afforded compounds 7a–c, 8a,b, and 13 which are analogues to MKC-442, TNK 561, and HEPT.

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