Abstract
A case of iodine-induced hypothyroidism is described. Quantitative information is presented concerning the iodine metabolism of the thyroid, with and without iodide blocking of hormonal synthesis. The following physiologic abnormalities were evident from the results of I131 tracer tests: greatly increased thyroidal iodide space, increased rate of transfer of iodide into the thyroid from plasma, and inhibition of organic binding of iodide. Hyperactivity of the iodide-accumulating function of the thyroid in the presence of high serum iodide levels offers no support for the theory that iodide inhibits the secretion or the action of TSH. One year after terminating all exogenous iodine and thyroid medication in this patient there was no laboratory or clinical evidence of any residual thyroid abnormality.
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