Abstract
Coenzyme Q (ubiquinone) is present in many rat tissues. However, its origin in these tissues, other than liver, is not well established. No deficiency state of coenzyme Q has so far been found. Even when the diet is free of coenzyme Q, tissue concentrations are not affected (Olson, Dialameh & Bentley, 1961; Lawson, Threlfall, Glover & Morton, 1961). The oral administration ofcoenzyme Qlo to rats increased the concentrations of this compound in liver and to a lesser extent in intestines, but no other tissues tested (heart, kidney, lungs, muscle) showed any change (Lawson et al. 1961). Under the conditions employed by Lawson et al. (1961), the absorption of small quantities by the tissues will not be detected and also, if a steady-state concentration of coenzyme Q is maintained, no changes would be observed. An attempt has therefore been made to study the distribution of coenzyme Q in rat tissues, including the foetus, by administering [14C]coenzyme Qlo orally, intracardially and intraperitoneally. Further, the capacity of the rat tissues for the synthesis of
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