Abstract
The particle-beam interface has recently been introduced for coupling liquid chromatography and mass spectrometry. The coupling of a particle-beam interface to a Finnigan MAT TSQ-70 triple quadrupole instrument is described. A compound-dependent peak broadening in the interface has been observed. In this paper various experiments are described to investigate some of the sources of peak broadening. For this purpose, the transfer efficiency of the particle-beam interface has been measured, and the potential of volatility-enhancing derivatization procedures has been explored. The detection of 40 pg of the pentafluorobenzyl derivative of palmitic acid is demonstrated.
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