Abstract
In 1950 Otto Wolff set up one of the first clinics in the United Kingdom specifically for the study and treatment of obesity in children. His original observations on the effects of over-nutrition on the development of children and of the outcome of hospital treatment (Wolff, 1955; Lloyd et al., 1961) have never been surpassed. His continuing interest in the subject has promoted work into many aspects cellular, biochemical, psychological and epidemiological and, together with the studies of numerous workers in many countries, has greatly enhanced our knowledge of this important nutritional disorder. Nevertheless many questions wait for answers and many problems for solutions. This review will discuss some of them. Because obesity in children is only rarely associated with endocrine diseases or other syndromes, these will not be considered here and the topic remains that of 'simple obesity' in itself a grave misnomer!
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