Some anthelmintic properties of octylchlororesorcinol against Ascaris lumbricoides in man.

Abstract

Among a series of highly effective alkylchlororesorcinols against Ascaris lumbricoides , effects of which were discovered in our laboratory in 1948/49 (1,2,3) as a result of systematic studies with the co-operation of Dr. Tomita and Dr. Uyeo (4,5,6) of the Pharmaceutical Institute of Kyoto University in the synthesis of these compounds, a member that proved lowest in toxicity as well as in local irritant action was 4- n -octyl-6-chlororesorcinol. Ashikaga (1) of our laboratory first studied clinical effects of this compound in 1949 and obtained satisfactory results, which, in due time, were confirmed by Hattori and his co-workers (7). For about a year after this there came forth no significant report on clinical studies of this compound. But, last year, reports by Hattori et al . (8) and by Inouye et al . (9) came out, and according to these reports, the efficacy of the compound seems to have suffered rather a severe diminution. Not only that but also, we too have discovered, after having examined two kinds of tablets of this compound prepared by a pharmaceutical Co., that, to our surprise, there occurred a great deal of deterioration in its efficacy compared to earlier data. Whereupon, we again examined the efficacy of three samples of crystalline octylchlororesorcinol that were synthetized since its first trial and found every one of them to be unsatisfactory.