Abstract
Antagonistic actions of β-blocking drugs on isoproterenol-induced lipolysis were studied in human omental adipose tissue. Competitive interaction characterized by the following pA 2 values was found: propranolol 8.7; trimepranol 8.7; practolol 7.1; H 35/25 6.0. The plot of pA 2 values of these drugs for human versus rat adipose tissue is linear with slope 2.0 indicating a higher differentiation of β-antagonist actions in human than in rat adipose tissue.
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Schedule a callMore From: European Journal of Pharmacology: Molecular Pharmacology
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