Abstract
Somatostatin and its anologue SMS 201-995 inhibit high voltage-activated (HVA) Ca 2+ currents in the rat insulinoma cell line RINm5F which stably express cloned human somatostatin receptor subtype 2 (hSSTR2). In contrast, neither somatostatin nor SMS 201-995 suppresses the HVA Ca 2+ currents in RINm5F which stably express cloned hSSTR1. These results suggest that somatostatin-induced inhibition of HVA Ca 2+ currents is mediated by a specific receptor subtype and that inhibition of calcium influx through HVA Ca 2+ channels is one of the mechanisms of SMS 201-995 action on inhibitory processes of hormone secretion and cell proliferation.
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