Abstract
The neuropeptide somatostatin is found in the retina of many species, yet its role in the visual process remains to be elucidated. The aim of the present study was to examine the expression and cellular localization of somatostatin receptor subtypes (sst; sst 2A, sst 2B and sst 3) in the eye of the adult newt Pleurodeles waltlii using immunohistochemistry. sst 2A immunoreactivity was observed in bipolar cells, in the inner segments of cone photoreceptors, as well as in the region corresponding to connecting cilia of rods. sst 2B immunoreactivity was not detected. sst 3 immunostaining was localized most intensely in the inner segments of cones, and in cilia of rods. These results suggest that somatostatin acting via sst 2A and sst 3 receptors may play an important role in retinal physiology of the lower vertebrates.
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