Abstract
Somatostatin or somatotropin release inhibiting factor (SRIF), a polypeptide found in the hypothalamus and in other tissues, 1,2 has been shown to inhibit the secretion of a number of hormones. 3 In regard to the extrahypophyseal actions of somatostatin, it has been reported that the hormone inhibits glucagon-stimulated gluconeogenesis and glycogenolysis in liver and that it affects the cyclic-AMP release. 4,5 Taking into account the role of the nucleotide system in the action of glucagon and the interrelationship between this hormone and somatostatin, it seemed of interest to study the somatostatin effect on glucagon-stimulated nucleotide release in rat liver slices in an attempt to better understand the action of somatostatin at the cellular level.
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