Somatosensory cortex and body representation: Updating the motor system during a visuo-proprioceptive cue conflict.

Abstract

The brain's representation of hand position is critical for voluntary movement. Representation is multisensory, relying on both visual and proprioceptive cues. When these cues conflict, the brain recalibrates its unimodal estimates, shifting them closer together to compensate. Converging lines of evidence from research in perception, behavior, and neurophysiology suggest that such updates to body representation must be communicated to the motor system to keep hand movements accurate. We hypothesized that primary somatosensory cortex (S1) plays a crucial role in conveying the proprioceptive aspects of the updated body representation to the motor system. We tested this hypothesis in two experiments. We predicted that proprioceptive, but not visual, recalibration would be associated with change in short latency afferent inhibition (SAI), a measure of sensorimotor integration (influence of sensory input on motor output) (Expt. 1). We further predicted that modulating S1 activity with repetitive transcranial magnetic stimulation (TMS) should affect variance and recalibration associated with the proprioceptive estimate of hand position, but have no effect on the visual estimate (Expt. 2). Our results are consistent with these predictions, supporting the idea that (1) S1 is indeed a key region in facilitating motor system updates based on changes in body representation, and (2) this function is mediated by unisensory (proprioceptive) processing, upstream of multisensory visuo-proprioceptive computations. Other aspects of the body representation (visual and multisensory) may be conveyed to the motor system via separate pathways, e.g. from posterior parietal regions to motor cortex.