Abstract
Abstract. In this review, we discuss the recent advances in somatic cell nuclear transfer (NT) in sheep, cattle, goats, swine and rabbits. Numerous advances have been reported as this technique has developed over the last five years. In the first part of this review, we describe the reported data pertaining to each of the species mentioned above. Theories are offered to explain the different results seen between different species and cell types. One of the main aspects of somatic cell NT, the production of transgenic animals will also be reviewed. Future applications of this powerful technique are discussed. This review concludes with a discussion of some of the problems observed in animals produced using NT as well as possible Solutions for these challenges.
Highlights
Nuclear transfer procedures originally required donor-cells from undifferentiated early embryonal stages
We summarize the advances that were achieved in sheep, cattle, goats, swine and rabbits in the last five years (Table 1)
We focus on the observed differences in developmental potential observed among different types of donor cells and describe reports of transgenic animals produced with the aid of nuclear transfer (NT)
Summary
We discuss the recent advances in somatic cell nuclear transfer (NT) in sheep, cattle, goats, swine and rabbits. One of the main aspects of somatic cell NT, the production of transgenic animals will be reviewed. Future applications of this powerful technique are discussed. Titel der Arbeit: Somatischer Kerntransfer bei landwirtschaftlichen Nutztieren In dieser Literaturtibersicht wird die Entwicklung des somatischen Kerntransfers bei landwirtschaftlichen Nutztieren dargestellt. Erfolge beim Rind, kleinen Wiederkäuer, Schwein und Kaninchen werden beschrieben. Da bei verschiedenen Tierarten und Spenderzellen unterschiedliche Effizienzen bei der Klonierung beobachtet wurden, werden in diesem Manuskript mögliche Gründe dafür diskutiert. Dabei wird auch insbesondere auf Probleme, die im Zusammenhang mit der Klonierung beobachtet werden, eingegangen.
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