Abstract
Thousands of noncoding somatic Single Nucleotide Variants (SNVs) of unknown function are reported in tumors. Considering the cis-regulatory landscape, we report somatic SNVs enrich in cistromes of prostate cancer driver transcription regulators, including AR, FOXA1 and HOXB13. This parallels enrichment of prostate cancer genetic predispositions over these transcription regulators’ cistromes, exemplified at the 8q24 locus harboring both risk-variants and somatic SNVs in cis-regulatory elements (CREs) upregulating MYC oncogene expression. Comparing primary prostate tumors and adjacent normal tissue, reveals the enrichment of somatic SNVs and risk-variants in tumor as opposed to normal cistromes. In conclusion, our results support a functional impact of somatic SNVs and germline risk-variants converging on CREs of cancer driver transcription regulators in prostate tumors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
