Abstract
Ninety-nine DNA samples of organs and tissues from 18 mice have been analyzed by the method of PCR amplification with random primers. Among the 27 oligonucleotide primers tested, four primers that yield stable, well-reproducible profiles of amplification products were chosen for further analysis. With two of these primers, the differences in the RAPD profiles of some tissues were detected in several individuals. These differences were associated with the modification of mobility or with the gain/loss of the fragment in the RAPD profile and could be caused by either genomic rearrangements or mutations involving the regions of DNA-primer pairing. Different epigenetic factors may also contribute to this process.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
