Abstract

Somatic modulation of ectopic action potential initiation in distal axons.

Highlights

  • Action potentials are initiated at the axon initial segment (AIS) when the summed depolarizing events arising from the dendrites exceed a threshold value

  • Sodium action potentials may be generated at regions remote from the AIS, that is, at ectopic sites located in the axon

  • Compared to AIS-evoked action potentials that are classically initiated on the top of a slow subthreshold depolarization such as an excitatory postsynaptic potential, Ectopic action potentials (EAPs) recorded in the cell body display a much lower threshold (ß −20 mV) (Hamada & Kole, 2015)

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Summary

Introduction

Action potentials are initiated at the axon initial segment (AIS) when the summed depolarizing events arising from the dendrites exceed a threshold value. Sodium action potentials may be generated at regions remote from the AIS, that is, at ectopic sites located in the axon.

Results
Conclusion
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