Abstract
Somatic modulation of ectopic action potential initiation in distal axons.
Highlights
Action potentials are initiated at the axon initial segment (AIS) when the summed depolarizing events arising from the dendrites exceed a threshold value
Sodium action potentials may be generated at regions remote from the AIS, that is, at ectopic sites located in the axon
Compared to AIS-evoked action potentials that are classically initiated on the top of a slow subthreshold depolarization such as an excitatory postsynaptic potential, Ectopic action potentials (EAPs) recorded in the cell body display a much lower threshold (ß −20 mV) (Hamada & Kole, 2015)
Summary
Action potentials are initiated at the axon initial segment (AIS) when the summed depolarizing events arising from the dendrites exceed a threshold value. Sodium action potentials may be generated at regions remote from the AIS, that is, at ectopic sites located in the axon.
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