Abstract
In the present work, the effects of various organic solvents (solvent nature and fraction within the solution) and solvothermal conditions on the formation of calcium-deficient hydroxyapatite (CDHA) via hydrolysis of α-tricalcium phosphate (α-TCP) are investigated. The wet precipitation method is applied for α-TCP synthesis, and the hydrolysis reaction is performed in solutions with different water-to-organic solvent ratios under solvothermal conditions at 120 °C for 3 h and at 200 °C for 5 h. Ethyl alcohol, isopropyl alcohol, and butyl alcohol did not inhibit the hydrolysis of α-TCP, while methyl alcohol and ethylene glycol have a more prominent inhibitory effect on the hydrolysis, hence the formation of single-phased CDHA. From all the solvents analysed, ethylene glycol has the highest impact on the sample morphology. Under certain water to ethylene glycol ratios and solvothermal conditions, samples containing a significant fraction of rods are obtained. However, samples prepared with ethylene glycol are characterised by a particularly low BET surface area.
Highlights
Hydroxyapatite (Ca10 (PO4 )6 (OH)2, HAp) is a major inorganic component in human hard tissue and is one of the most investigated calcium phosphates (CaPs) [1,2,3]
Previous studies have reported a larger specific surface area and superior incorporating efficacy of calcium-deficient hydroxyapatite (CDHA) when compared to other CaPs [13,14]
As far as we know, no comprehensive study has ever been performed to compare the effects of different organic solvents on the hydrolysis of αtricalcium phosphate (α-TCP) under solvothermal conditions
Summary
Hydroxyapatite (Ca10 (PO4 ) (OH) , HAp) is a major inorganic component in human hard tissue and is one of the most investigated calcium phosphates (CaPs) [1,2,3]. Due to its bone-like chemical composition and crystalline structure, HAp is extensively applied as bioceramic material for bone grafting [4,5]. HAp has found applications in drug delivery [6], chromatography [7], and is a very promising material for the treatment of air, water, and soil pollution [8,9,10,11]. Calcium-deficient hydroxyapatite (CDHA, Ca10−x (HPO4 )x (PO4 )6−x (OH)2−x ) is HAp with a Ca/P ratio from. The chemical composition of HAp can be modified from the stoichiometric form to the Ca-deficient form by selecting an appropriate Ca/P molar ratio [15]
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