Abstract
AbstractTwo novel, namely 5-Phenyl-4-methyl-1, 2, 3-selenadiazole (5h) and 4-Phenyl-5-propyl-1, 2, 3-selenadiazole (5i) along with several other aliphatic and aromatic series of 1,2,3-selenadiazoles were synthesized at room temperature in one step under solventless conditions from the corresponding semicarbazones. All compounds were thoroughly characterized by various spectroscopic tools. The synthesized new and reported 1,2,3-selenadiazoles were found active against bacterial as well as fungal stains when screened for their antimicrobial activity against various pathogenic bacteria and fungi using agar disc diffusion as well as agar well diffusion method. Almost all selenadiazoles showed better antibacterial properties in comparison to established antibiotics like tetracycline. 4-ethyl-5-methyl-1,2,3-selenadiazole showed higher antimicrobial activity amongst the tested selenadiazoles.
Highlights
The current interest in the chemistry of 1,2,3-selenadiazoles is mainly due to their chemical reactivity owing to their soft transformations upon thermolysis (Jadhav, Dhanwe, Joshi, & Khanna, 2015; Junling et al, 2004) and or photolysis that derive free selenium via elimination of a nitrogen molecule leading to formation of alkynes or new heterocycles (Jadhav, Dhanwe, et al, 2015; Meier & Voigt, 1972; Regitz & Krill, 1996; Jadhav & Khanna, 2015)
This paper presents some novel compounds along with different series of heterocyclic organoselenium compounds i.e. 1, 2, 3-selenadiazoles synthesized at room temperature under solventless condition from corresponding semicarbazones and SeO2
In the current work, we present the synthesis of two novel 1,2,3-selenadiazoles (5h,i) and comparative study of antimicrobial behavior of different series of 1,2,3-selenadiazoles
Summary
The current interest in the chemistry of 1,2,3-selenadiazoles is mainly due to their chemical reactivity owing to their soft transformations upon thermolysis (Jadhav, Dhanwe, Joshi, & Khanna, 2015; Junling et al, 2004) and or photolysis that derive free selenium via elimination of a nitrogen molecule leading to formation of alkynes or new heterocycles (Jadhav, Dhanwe, et al, 2015; Meier & Voigt, 1972; Regitz & Krill, 1996; Jadhav & Khanna, 2015) Such new transformations make selenadiazoles and the end compounds thereof useful in pharmaceutical chemistry as well as precursors for coordination (Zhan, Liu, Fang, Pannecouque, & Clercq, 2009; Cervantes-Lee et al, 1998; Morley & Vaughan, 1993; Ford, Khanna, Morley & Vaira, 1999; Khanna & Morley, 1993) and materials chemistry including nanotechnology. The researchers are continuously in the hunt for new molecules for controlling the bacterial infection timely and more effectively
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