Solvent-Free Synthesis of Novel Benzodiazepine Derivatives by a Three-Component Base-Catalysed Reaction of Isatoic Anhydride, a Primary Amine and Chloroacetyl Chloride

Abstract

Heating isatoic anhydride with a series of primary amines at 150 °C under solvent-free conditions yielded 2-amino-N-alkylbenzamides which, in the same pot, reacted readily with chloroacetyl chloride in the presence of poly(dimethylaminoethyl acrylamide)-modified magnetic nanoparticles ( MNP@PDMA ), a base catalyst, to give 4-alkyl-1,4-benzodiazepine-2,5-diones in good yields without formation of by-products.