Abstract
A novel efficient method for the synthesis of ferrocenyl chalcone Schiff bases and their metal (II) complexes has been developed. Schiff bases were synthesized with TsOH (p-toluenesulfonic acid) as catalyst and complexed with metal (II) salts (Zn (II), Pb (II), Cd (II), Ni (II)). The compounds were characterized by various spectroscopic techniques and elemental analysis. The thermal stability of the complexes was performed by thermogravimetric analysis (TGA). In addition, The ligands and their metal complexes have been screened in vitro antibacterial (S. aureus, Streptococcus, Actinomycete, E. coli and P. aeruginosa), antifungal properties (C. albicans, A. fumigatus, A. niger, A. flavus, S. cerevisiae). The results revealed that Zn (II) complexes (H1, H5, H9) were the most active against all bacterial and fungal strains.
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