Abstract
This work describes the application of organo-modified SBA-15 siliceous materials as the carrier for niacinamide. The surface functionalization of SBA-15 by a grafting strategy with triethoxyphenylsilane, triethoxy(4-methoxyphenyl)silane, triethoxymethylsilane and (3-mercaptopropyl)trimethoxysilane as modifying agents has been successfully achieved. The adsorption process was performed in acetonitrile, methanol, 2-propanol, 1-pentanol and ethyl acetate. The obtained results indicated a promote niacinamide adsorption on sulfopropyl-modified (119mg/g) and non-modified (78mg/g) SBA-15 from ethyl acetate. The pure and derivatized SBA-15 products have been characterized by elemental analysis, thermogravimetry, nitrogen adsorption and diffuse reflectance UV spectroscopy. After niacinamide adsorption the textural parameters of mesoporous carriers such as BET surface area, pore volume and microporosity were reduced. The mesoporous matrices loaded with niacinamide exhibited prolonged-release kinetics of this vitamin, especially from sulfopropyl-modified SBA-15 carrier.
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