Abstract
In this paper we wish to report the solvent free synthesis of 1-acetyl-3-(4-fluoronaphthyl)-5-substituted aryl pyrazolines by using simple and efficient Green Chemistry techniques (Grindstone method and microwave irradiation). These methods have been developed for the rapid solvent free synthesis of title compounds from corresponding chalcones and hydrazine hydrate or phenylhydrazine in acetic acid. Considerable increase in the reaction rates have been observed with better yields compared with sample prepared from conventional method. Structure of synthesized new compounds have been confirmed on the basis of spectral (IR, 1 H NMR) and analytical data. Representative compounds have been screened for their spermicidal activity in HF cattles and Murrah buffalo.
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