Abstract
The solvent-free microwave-assisted syntheses of N-alkyl isatin Schiff base derivatives are reported. These isatin derivatives are obtained as a result of the condensation of an isatin compound with a benzyl halide and an aniline derivatives using microwave irradiation condition in high yield and short reaction time. KEY WORDS : Microwave, Isatin derivatives, Solvent free, Combinatorial synthesis Bull. Chem. Soc. Ethiop. 2018 , 32(2), 393-398. DOI: https://dx.doi.org/10.4314/bcse.v32i2.17
Highlights
Microwave-assisted organic synthesis (MAOS) is a new method for synthesis and methodology in formation of new organic compounds
In continuation to our interest in synthesis of new biologically active compounds, here, we report the synthesis of some Schiff bases and N-alkylated Isatin derivatives in good yields and short time in solvent free and microwave irradiation condition [20, 21]
Reaction of isatin with benzyl chloride and aryl amines was investigated under microwave irradiation in solvent free condition
Summary
Microwave-assisted organic synthesis (MAOS) is a new method for synthesis and methodology in formation of new organic compounds. Few synthesis methods have reported the use of microwave reactions for synthesis of organic and organometallic compounds [18, 19].
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