Abstract
This study aimed to synthesize 4'-hydroxy-4-hydroxy chalcone from 4-hydroxy acetophenone and 4- hydroxybenzaldehyde by a solvent-free method using a grinding technique and determine its potential as an antibacterial against Staphylococcus aureus and Escherichia coli. Synthesis of 4'-hydroxy-4-hydroxy chalcone was conducted using the Claisen-Schmidt method of grinding for 30 minutes. The grinding results were then extracted with chloroform. The formed crystals were tested for purity by thin-layer chromatography (TLC), and recrystallization was carried out to purify the compound. FTIR, 1H-NMR, and 13C-NMR characterized the synthesized chalcone. The synthesized chalcone was determined for antibacterial activity using the disc method against Staphylococcus aureus and Escherichia coli. The results showed that 4'-hydroxy-4-hydroxy chalcone could be synthesized from 4-hydroxy acetophenone and 4-hydroxy benzaldehyde by grinding technique in orangish white crystals form (yield of 66.67%) and a melting point of 85-88°C. The synthesized chalcone has low antibacterial potential against Staphylococcus aureus and Escherichia coli.
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