Abstract
Amide functional groups are prominent in a broad range of organic compounds with diverse beneficial applications. In this work, we report the synthesis of these functional groups via an iron(iii) chloride-catalyzed direct amidation of esters. The reactions are conducted under solvent-free conditions and found to be compatible with a range of amine and ester substrates generating the desired amides in short reaction times and good to excellent yields at a catalyst loading of 15 mol%.
Highlights
Amide functional groups are present in a plethora of natural and organic molecules with beneficial applications in the pharmaceutical, agrochemical, and textile industries
We report the direct amidation of esters using relatively cheap used to promote ester amidation
We report the direct amidation of esters using investigation of more catalysts as well as different amino substrates that can be used to promote
Summary
Amide functional groups are present in a plethora of natural and organic molecules with beneficial applications in the pharmaceutical, agrochemical, and textile industries. Nickel has been employed by Newman and co-workers for direct amidation of methyl esters at high reaction temperatures [24]. There is a growing interest in the use of esters as substrates for direct amidation reactions.
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