Abstract
Two pairs of cinchona alkaloids, quinine/quinidine and cinchocine/cinchonidine, were extracted by ion-pair formation with some anions of camphor derivatives. The extraction behvaiors are examined, and the differences between the two isomers compared. These alkaloids were extracted into chloroform and 1,2-dichloroethane in the pH range 4-7 as a 1:1 ion-pair with chiral anions. The relationship between the distribution ratio of the ion-pair and pH is discussed. In the pH range between the pK a1 and pK a2 values of cinchona alkaloids, the extraction constants were determined, and the differences caused by the effect of substituents of cinchona alkaloids and counter ions were examined. The solvent effect were also studied
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