Abstract
The antioxidant activity of three different classes of flavonoids including naringenin (flavanon), chrysin (flavone), and daidzein (isoflavone) as well as their complexes with Ce(IV) were assayed in different aqueous solutions of DMSO (50–80% v/v) at physiological pH using a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method. The radical scavenging activity (RSA) of the samples was influenced by changes in solvent composition, and their variations were analyzed using the normalized polarity parameter (ETN) and Kamlet, Abboud, and Taft (KAT) equation. A very good linear correlation of the RSA versus ETN and also two parameters of KAT including π* (dipolarity/polarizability) and α (hydrogen-bond donating acidity) was obtained. The RSA values of the samples are also determined by the Yasuda–Shedlovsky extrapolation method at 0% of the organic solvent. Furthermore, it was found that the metal chelation enhances the RSA of the flavonoids.
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