Abstract
A highly efficient solvent-controlled synthesis of bis(trifluoromethyl)cyclopropanes and bis(trifluoromethyl)pyrazolines via a [2 + 1] or [3 + 2] cycloaddition reaction of 2-trifluoromethyl-1,3-conjugated enynes with CF3CHN2 was developed. The reactions of 2-trifluoromethyl-1,3-conjugated enynes with CF3CHN2 proceeded smoothly under transition-metal and base-free conditions, affording the expected cycloaddition products in good to excellent yields. When DMAc (N,N-dimethylacetamide) was used as the solvent, bis(trifluoromethyl)pyrazolines were obtained; however, in contrast, bis(trifluoromethyl)cyclopropanes were formed by changing the solvent from DMAc to DCE (1,2-dichloroethane).
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