Solvent- and catalyst-free synthesis of imidazo[1,2-a]pyridines under microwave irradiation

Abstract

A facile solvent- and catalyst-free method for the synthesis of a series of imidazo[1,2-a]pyridines in good to excellent yields by the condensation of 2-aminopyridines with α-bromoketones under microwave irradiation has been developed. The important features of this method are that it is reasonably fast, very clean, high yielding, simple workup and environmentally benign.