Abstract
It has been found that microwave assisted decarboxylation of malonic acid derivatives can be achieved under solvent-free and catalyst free conditions. This new method produces the corresponding carboxylic acid in a pure manner and with a high yield in a very short reaction time: 3 - 10 min. In general terms, the condition under which this reaction is carried out accelerates the decarboxylation significantly of a series of disubstituted malonic acid derivatives, and makes this new process efficient, easy and environmentally friendly.
Highlights
The synthesis of carboxylic acid derivatives via malonic ester alkylation, hydrolysis, and subsequent decarboxylation is a well-established method for carboncarbon bond formation [1] [2] [3], and it is one of the most important reactions in organic synthesis
It has been found that microwave assisted decarboxylation of malonic acid derivatives can be achieved under solvent-free and catalyst free conditions
We report the solvent- and catalyst-free microwave-assisted decarboxylation of malonic acid derivatives; the decarboxylation process takes around 10 min at 200 W, 180 ̊C - 190 ̊C in an open vessel system
Summary
The synthesis of carboxylic acid derivatives via malonic ester alkylation, hydrolysis, and subsequent decarboxylation is a well-established method for carboncarbon bond formation [1] [2] [3], and it is one of the most important reactions in organic synthesis. Each of these steps is under constant revision with the aim of developing more efficient procedures in terms of stereocontrol, use of friendly reaction conditions and better yields [4].
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