Abstract
Drug solubility is a key parameter during the processes associated to design and development of new liquid pharmaceutical dosage forms. Cosolvency is a commonly used technique to increase the drug solubility in several orders of magnitude and it is relatively simple. Nevertheless the solubility in mixed solvents is scarce for several drugs. For this reason, in this work the solubility of indomethacin was determined by using the stirred flask method as a function of temperature and cosolvent composition in some ethanol+propylene glycol mixtures. From solubility data the solution thermodynamic quantities, Gibbs energy, enthalpy and entropy, were calculated. In similar way, from these new values and information about drug melting properties, the thermodynamic quantities of hypothetical liquids mixing were also calculated. A non-linear ΔsolnH° vs. ΔsolnG° compensation plot was obtained which could indicate that the dissolution mechanism is dependent on the cosolvent mixture composition.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
