Abstract

AbstractA 14C‐labeled pentapeptide, [14C]Arg‐Lys‐Asp‐Val‐Tyr (6), corresponding to the active fragment 32–36 of thymopoietin II has been synthesized by a solution method with a 44 percent radiochemical yield. 14C‐labeled Z‐Arg(HCl)‐OH was coupled to the protected tetrapeptide Lys(Z)‐Asp(OBzl)‐Val‐Tyr(Bzl)‐OBzl using dicyclohexylcarbodiimide and 1‐hydroxybenzotriazole to give the protected pentapeptide 5 with a specific activity of 340 mCi/mmol. Catalytic transfer hydrogenation was used to remove the protecting groups and the free peptide was purified by gel filtration and high performance liquid chromatography.

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