Abstract
Noroviruses are the leading cause of acute food- or water-borne gastroenteritis outbreaks in humans with an estimated 23 million annual cases in the US alone and show high diversity with at least five genogroups (GI-GV). Norwalk virus (NV) is a prototype strain classified as GI strain. Noroviral RNA genome is composed of three open reading frames (ORFs), and the ORF1 encodes a polyprotein that is cleaved by the viral 3C-like cysteine protease (Pro) into 6 non-structural proteins, which makes the Pro as an essential component for the viral replication as well as an attractive target for antiviral drug development.
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