Abstract
ABSTRACT A method for the synthesis of O-thymidin-3′-yl S-alkyl dithiophosphate monomers 1 with different S-protecting groups has been developed. These have been used for solution phase synthesis of dithymidine phosphorodithioate by a new phosphotriester method. Coupling reactions are fast (15 min.) and the products are free from phosphorothioate contaminations.
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