Abstract
Solution conformations of amphidinolide H ( 1), a 26-membered macrolide exhibiting potent cytotoxic and antitumor activity, in CDCl 3 and DMSO- d 6 were investigated on the basis of NMR data, distance geometry calculation, and restrained energy minimization. Three-dimensional conformations in CDCl 3 were suggested to be close to the X-ray structure of 1, while those in DMSO- d 6 were indicated to be different from both those in CDCl 3 and the X-ray structure.
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