Solution and Solid Phase Synthesis of Pteridines, Purines and Related Compounds

S. La Rosa,C. J. Suckling,D. Guiney,P. H. Boyle,C. L. Gibson

doi:10.1007/978-1-4615-0945-5_4

Solution and Solid Phase Synthesis of Pteridines, Purines and Related Compounds

S. La Rosa, C. J. Suckling + Show 3 more

https://doi.org/10.1007/978-1-4615-0945-5_4

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Publication Date: Jan 1, 2002

Citations: 1

Affiliation: University of Strathclyde, Trinity College Dublin

#Series Of Pteridines #Sulfur Linker + Show 8 more

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Abstract

This paper describes the solution and solid phase synthesis of different heterocyclic systems from the common intermediate 6 and 16. A series of pteridines, purines and a 7-deazaguanine have been synthesized in solution. The chemistry has been transferred to the solid phase using a polystyrene resin through a sulfur linker. Cleavage of the resins has been achieved by oxidation followed by nucleophilic displacement.KeywordsSolid Phase SynthesisAldol ReactionAmino PyrimidineCommon IntermediatePolystyrene ResinThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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