Abstract
The formation thermodynamics of a new 1 : 1 sulfamethazine–3-methylsalicylic acid co-crystal reveals spontaneity of formation associated with a positive enthalpy change.
Highlights
Many active pharmaceutical ingredients (APIs) fall in the Biopharmaceutics Classification System (BCS) class II category, signifying a high permeability but low solubility.[1]
For the API in this study, sulfamethazine (SMT), which exists as a single polymorphic form, the number of cocrystals reported in the literature is around 33.12 A few solvates for SMT are reported in the literature.[13]
The crystal structure belongs to the Pbca space group
Summary
Many active pharmaceutical ingredients (APIs) fall in the Biopharmaceutics Classification System (BCS) class II category, signifying a high permeability but low solubility.[1]. A relationship between the size of the region in the ternary phase diagram where the cocrystal is the stable solid phase and the coformer to API solubility ratio is shown in the present work.
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