Abstract
Solute kinetics in peritoneal dialysis (PD) have been extensively studied from the therapy’s beginnings. Peritoneal physiology has been summarized in mathematical models of medium complexity that produce a good phenomenological description of molecular transport (1–3). However, the biologic nature and the composite structure of the peritoneum may leave some uncertainty in these descriptions. Moreover, possible acute adaptive variations in peritoneal physiological characteristics, plus progressive pathological structural modifications, may need more a complex description (4). Automated peritoneal dialysis (APD) is a galaxy of treatments that have in common the use of automatic machines for fluid exchanges and the high efficiency obtained through short dwell times, high dialysate flows, and high intraperitoneal volumes (5,6). With regard to these features, solute kinetics in APD present unique aspects that need to be elucidated for effective prescription.
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