Solute and Water Transport during Continuous Arteriovenous Hemofiltration (CAVH)

Abstract

The transport mechanisms governing solvent and solute removal during CAVH were elucidated on the basis of in vitro and in vivo observations. Using a typical hemofilter (Diafilter D-20, AMICON), filtration rate rose with inlet blood flow rate until an asymptote was reached at blood flows of approximately 150 ml/min. The onset of the asymptote coincided with transition from a regime controlled by oncotic pressure (filtration pressure equilibrium), to one governed by simple Darcy's law filtration behaviour. Subsequent measurements showed that under clinical conditions, CAVH is generally in the pre-asymptotic regime and operates at filtration pressure equilibrium. These observations offer the theoretical bases for a new design for CAVH hemofilters. As a possible corollary, middle-molecule sieving coefficients were found to be stable with time during CAVH in vivo, whereas in chronic mechanical hemofiltration they declined significantly during clinical treatment. The sieving coefficients, however, were lower in mechanical hemofiltration from the beginning of the session. These observations suggest that the measured sieving coefficient for a membrane is not necessarily a constant directly and solely related to the membrane standard reflection coefficient for a given solute. Concentration polarization and the ultrafiltration rate per unit of surface area may in fact have a major effect on the final concentration of solutes in the ultrafiltrate.