Abstract
BackgroundSoluble urokinase receptor (suPAR) may be involved in the pathological mechanisms of focal segmental glomerulosclerosis (FSGS) changes. However, it remains unclear whether suPAR is correlated with the FSGS-like lesions in IgA nephropathy (IgAN).MethodsWe measured the plasma suPAR levels in 138 patients with IgAN, and then their clinical and pathological relationships were analyzed.ResultsWe found that the plasma suPAR levels were significantly correlated with age and renal function by both univariate and multivariate analysis in our IgAN patient cohort. Female had higher plasma suPAR levels and no significant correlation was observed between plasma suPAR levels and 24-h urine protein and highly sensitive C-reaction protein with multivariate analysis. In our cohort, sixty of these IgAN patients could be diagnosed with a type of FSGS lesions. The plasma suPAR levels were higher in the IgAN patients with FSGS lesions than in the IgAN patients without FSGS lesions by univariate (P < 0.0001) and multivariate (P < 0.001) analysis adjusting for other predictor variables, which might be helpful to differentiate the pathological changes with and without FSGS lesions. And the optimal cutoff value was 1806 pg/ml in this study. The plasma suPAR concentrations were also associated with the degree of tubular atrophy/interstitial fibrosis in both univariate and multivariate analysis. In multivariate analysis, the plasma suPAR levels were correlated with the percentage of crescents, not global sclerosis and arterial lesions.ConclusionsOur study suggested that the plasma suPAR levels were associated with age, gender, renal function, the degree of tubular atrophy/interstitial fibrosis and the percentage of crescent formation. The plasma suPAR might be a potential predictor for the presence of FSGS pathological lesions in Chinese patients with IgAN.
Highlights
IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide and defined by an IgA-dominant deposition within the glomerular mesangium [1]
We found that the plasma suPAR levels were significantly correlated with age and renal function by both univariate and multivariate analysis in our IgAN patient cohort
The plasma suPAR levels were higher in the IgAN patients with focal segmental glomerulosclerosis (FSGS) lesions than in the IgAN patients without FSGS lesions by univariate (P < 0.0001) and multivariate (P < 0.001) analysis adjusting for other predictor variables, which might be helpful to differentiate the pathological changes with and without FSGS lesions
Summary
IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide and defined by an IgA-dominant deposition within the glomerular mesangium [1]. Previous studies have shown that several clinical factors, such as heavy proteinuria, uncontrolled hypertension, and renal dysfunction, can be used to predict the prognosis in IgA nephropathy. Both nephrologists and pathologists have attempted to discover the clinical relevance of these histopathological changes [1, 3,4,5,6]. Soluble urokinase receptor (suPAR) may be involved in the pathological mechanisms of focal segmental glomerulosclerosis (FSGS) changes. It remains unclear whether suPAR is correlated with the FSGS-like lesions in IgA nephropathy (IgAN).
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