Soluble ST2 predicts 1‐year outcome in patients undergoing transcatheter aortic valve implantation

Abstract

Soluble ST2 (sST2) has been introduced as a novel biomarker in patients suffering from heart failure for risk stratification. In this study, we sought to investigate whether sST2 is useful for risk stratification and prediction of mortality in patients undergoing transcatheter aortic valve implantation (TAVI). A total of 274 patients undergoing TAVI were included in this study (149 female; age 81±1years; EUROSCORE 25±1; STS score 3·8±0·2). Plasma samples were obtained preinterventional and analysed for sST2. Patients were followed up 1month and 1year after TAVI. In a Cox regression analysis, sST2 plasma concentration was associated with increased mortality (changes per pg/mL sST2 concentration; HR 1·00006 95% (1·00004-1·00009); P<0·001). A cut-off by means of the Youden Index was calculated (10070·27pg/mL), and patients were retrospectively divided into two cohorts, in those above (31·3%) and those below (68·7%) this value. These two groups were then compared regarding mortality both after 30days and 1year: whereas 1-month mortality did not differ (7·0% vs. 10·3%, OR 1·50 95% CI (0·60-3·79; P=0·46)), patients with a sST2 concentration above the cut-off of 10070·27pg/mL showed a significantly worse outcome after 1year (49·2% vs. 23·2%; OR 3·21 95% CI (1·70-6·04); P<0·001). After correction for confounders in a multivariate Cox regression analysis, sST2 (1·0002 95% CI (1·0001-1·0003); P=0·001) concentration remained associated with mortality. sST2 levels were associated with 1-year mortality after TAVI. Based on these results, we assume that sST2 might help to identify patients at high risk for death in whom conservative treatment should be considered.